在细胞核内，HMGB1有助于DNA修复、染色体维持和细胞周期调节。一旦在细胞外释放，它就会与RAGE和TLR4等受体结合，放大炎症信号，并通过激活免疫细胞导致肝脏损伤。此外，HMGB1在自噬中发挥作用，自噬是细胞存活和肝组织再生不可或缺的过程。 受体和信号通路 ...

HMGB1 also contributes to autophagy, which is essential for liver tissue regeneration and cell survival. Upon binding with RAGE and TLR4, HMGB1 activates pro-inflammatory pathways that exacerbate ...

HMGB1's interactions with its primary receptors, RAGE and TLR4, are essential to its role in liver disease. Upon binding, these receptors initiate pro-inflammatory signaling pathways such as the ...

It's an often-used phrase in bike media, but a tyre upgrade is about the best bang for your buck as far as upgrades go. New bikes are often specced with cheaper tyres in order to hit a price point ...

Somehow, The Binding of Isaac: Rebirth celebrates its tenth anniversary this week, and, to mark the occasion, developer Edmund McMillen has announced the poop-obsessed roguelike's long-awaited ...

The Binding of Isaac Rebirth is ten years old. Since it launched, some of my other favorite roguelikes have taken up all my attention, but it’s almost time for the return of the king.

It is alluded by the authors that TLR activating adjuvants mediate selective, low affinity, exogenous peptide binding onto MHC class II molecules. However, this was not demonstrated to be related ...