Hosted on MSN1mon
New drug for prostate cancer patients in clinical trials
NXP800 works in an innovative way, by targeting the Heat Shock Factor 1 (HSF1) pathway—a "master switch" in cells that is hijacked to support the growth of cancer cells, helping them withstand ...
Nature11y
Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes
Here, we show that deletion of the main transcription factor involved in heat shock gene regulation, heat shock factor 1 (HSF1), affects M-CSF-driven differentiation of mouse bone marrow cells.