C&EN1 个月
Design, Synthesis, and SAR of Covalent KIT and PDGFRA Inhibitors─Exploring Their ...
Department of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Otto-Hahn-Strasse 4a, Dortmund 44227, ...
C&EN2 个月
Novel Bicyclic Amines as CDK2 Inhibitors for Treating Metastatic Breast Cancer or ...
Further, the application discloses compounds and their preparation, use, pharmaceutical composition, and treatment. The CDK2/Cyclin E1 HTRF enzyme activity assay was performed. The compounds described ...
eLife3 年
Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner
The primary cilium is a paradigmatic organelle for studying compartmentalized cellular signaling in morphogenesis and disease (Anvarian et al., 2019; Nachury and Mick, 2019). The primary cilium is a ...