Objective Although glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor-β superfamily, its function in liver fibrosis has rarely been studied. Here, we ...

ECM can directly influence the function of surrounding cells through interaction with cell surface receptors, including integrins and nonintegrin matrix receptors (such as discoidin domain ...

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Primary murine hepatic stellate cells (HSCs) and human HSC line Lx2 were used to investigate the impact of HLF on HSC activation and the underlying mechanism. Results Expression of HLF was detected in ...

The paradigm of stellate ... by stellate cells, antagonists have been tested as both antifibrotic and portal hypotensive agents. Alternatively, delivery of NO to injured liver may have the same ...

Tissue samples are removed from your liver and checked under a microscope for signs of damage or disease. A liver biopsy can tell if there are cancer cells or other abnormal cells in your liver. It ...

Its essence is liver tissue remodeling caused by excessive accumulation of collagen and other extracellular matrix. Activation of hepatic stellate cells (HSCs), which are responsible for collagen ...

Addressing this, the researchers present, for the first time, a technique for targeted protein degradation within the mitochondria of yeast and human cells. They have also devised a way to control the ...

Chemotherapy (chemo) is treatment with certain kinds of drugs that destroy cancer cells. At one time, chemo was often the first treatment for more advanced liver cancers. But newer types of treatment, ...