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生物通
4 天
李劲松组揭示染色体融合后染色体在核内的空间位置变化
早在 2022 年,李劲松研究组报道了利用类精子干细胞介导半克隆技术,通过 CRISPR/Cas9 靶向染色体重复序列实现小鼠染色体融合改造,建立全新的稳定传递的染色体改造纯和小鼠品系,揭示了染色体融合的机制,并提示真核生物基因组组装的系统稳健性( Robustness ...
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