Sarepta Therapeutics, Inc. (NASDAQ:SRPT), the leader in precision genetic medicine for rare diseases, today reported ...

Background: The Homeobox (HOX) gene family are conserved transcription factors that are essential for embryonic development, oncogenesis, and cancer suppression in biological beings. Abnormally ...

Investigating the relationship between IL-1 and inflammation in inflammatory bowel disease (IBD), researchers unveiled mesenchyme homeobox 1 (MEOX1), an IL-1-dependent transcription factor that is ...

A research team has identified the transcription factor Lhx2 (LIM homeobox protein 2) as a key regulator in hepatic stellate cells. Lhx2 was found to simultaneously promote liver regeneration and ...

Avidity Biosciences specializes in RNA-based therapies using Antibody-oligonucleotide conjugates to deliver drugs directly to ...

A guardian molecule ensures that liver cells do not lose their identity. This has been discovered by researchers from the ...

The new drug candidate for FSHD will combine an RNA molecule from miRecule targeting double homeobox 4 (DUX4) – a protein that is mutated in FSHD – with a nanobody developed by Sanofi that ...

团队前期研究表明，MSX1可通过直接结合增强子II/核心启动子（EnII/Cp）并抑制其启动子和增强子活性来抑制HBV的基因表达和复制。除了上述调控机制外，MSX1还在转录后水平下调HBx蛋白的稳定性，且不受HBX基因型的影响。进一步证实，MSX1通 ...

The research team found almost 30 different guardian candidates and decided to pursue one of them further: PROX1 (Prospero homeobox protein 1). Studies on the liver cancer model showed that the team ...

The responsible metabolic lesion appears to involve a posttranscriptional defect in pancreas duodenum homeobox-1 (PDX-1) mRNA maturation. PDX-1 is a critically important transcription factor for ...