HIF1α identified as crucial for T cell activation in oxygen-poor tumors
Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their ...
News Medical on MSN7 小时
Key regulator that induces cancer-killing capacity in T cells under hypoxia is identified
The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen, and it may be involved in resistance to immune ...
Armed robbery in Revesby17 天
Cross-Species Interferon Pathway Variability Studied
including the entry proteins ACE2 and transmembrane serine protease 2 (TMPRSS2); 21 proteins in the interferon-I (IFN-I) antiviral response pathway; and tethrin, a protein that suppresses new virion ...
Science Daily2 天
Brain Tumor News
Researchers Develop Promising Therapy Treatment That Can Kill Glioblastoma Cells in Newly Discovered Brain Pathway Aug. 2, 2024 — A new pathway that is used by cancer cells to infiltrate the ...
GEN11 天
Cancer Immunotherapy Could Turn Up the Heat on Cold Tumors by Suppressing UBA1
Prostate cancer and other cancers characterized by “cold” tumors could become more responsive to checkpoint blockade if UBA1 is inhibited.
BMJ11 天
Activation of the STAT1 pathway in rheumatoid arthritis
1 Department of Molecular Cell Biology, VU Medical Centre/VU University Amsterdam, 1081 BT Amsterdam, The Netherlands 2 Division of Clinical Immunology and Rheumatology, Academic Medical ...
Targeted Oncology16 天
New Study Identifies Effective Treatments for Melanoma-Associated Leptomeningeal Disease
In an interview, Vincent Law, of Moffitt Cancer Center, discussed a new study that offers hope for patients with melanoma ...