Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their ...

Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has ...

The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen, and it may be involved in resistance to immune ...

Acquired resistance to PD-L1 inhibition can rewire the interferon-regulated secretory machinery in tumor cells, altering the ...

Prostate cancer and other cancers characterized by “cold” tumors could become more responsive to checkpoint blockade if UBA1 is inhibited.

Bacterial and parasitic infections cause the production of the cytokine interferon-gamma (IFNy) which triggers broad anti-microbial activities active in macrophages, but also in non-immune cells. They ...

In an interview, Vincent Law, of Moffitt Cancer Center, discussed a new study that offers hope for patients with melanoma ...

including the entry proteins ACE2 and transmembrane serine protease 2 (TMPRSS2); 21 proteins in the interferon-I (IFN-I) antiviral response pathway; and tethrin, a protein that suppresses new virion ...

The paradigm of stellate cell activation provides an important framework for defining sites/targets of antifibrotic therapy (Table; see [54] for review). These strategies include: (A) curing the ...

The country offers a good pathway for graduates because of their interest in conserving talents. Clear post-study permanent residency pathways make Australia one of the most sought-after ...