This valuable work presents how PRDM16 plays a critical role during colloid plexus development, through regulating BMP signaling. Solid evidence supports the context-dependent gene regulatory ...

Ray Lambert looks at the potential of humanized FcRn mice for evaluating the pharmacokinetics of mAbs. Due to their extraordinary specificity and pharmacokinetic (PK) behavior, human ...

In obesity, B cells accumulate in white adipose tissue (WAT) and produce IgG, which may contribute to the development of glucose intolerance. IgG signals by binding to Fcγ receptors (FcγR ...

BCR signaling plays a crucial role in the pathogenesis of CLL. 2,9,10 Activation of this pathway fosters an ideal leukemic microenvironment, promoting CLL cell proliferation and survival. 2 BCR ...

Kentucky basketball embarked on a new era in the 2024-25 season, moving from legendary coach John Calipari to Mark Pope, a former Wildcats player who was hired to replace Calipari after he was ...

3Department of Pathology, Yale School of Medicine, New Haven, Connecticut. 4Department of Dermatology, Yale School of Medicine, New Haven, Connecticut. 5Yale Center for Precision Cancer Modeling, Yale ...

B cell receptor (BCR) signaling plays a fundamental role in B cell development, activation, and antibody responses. The BCR consists of a membrane immunoglobulin (mIg), the antigen recognition subunit ...

Drugs that specifically inhibit BCR signaling elements are currently being tested in clinical trials. The promising results obtained so far suggest that in the near future we may have novel ...

For instance, a single dose of a COVID-19 mRNA vaccine may generate high levels of IgG targeting the receptor-binding domain ... also been suggested that IgD signaling can be a novel therapeutic ...

PRRT is a possible treatment for some NETs that start in the pancreas or the digestive system. It is not a treatment for NECs. Radioisotope therapy uses radioactive medicines to treat some cancer ...

We further report the functional characterization in flies of one family of these genes, encoding for nicotinic acetylcholine receptor (nAchR) subunits. We find that nAchR signaling in enterocytes of ...