The cell and gene therapies in rare disorders market is expected to grow at a significantly high rate during the forecast period (2025–2034) and main ...

Finally, Regenxbio is working on RGX-121, an AAV9 vector to deliver the human iduronate-2-sulfatase gene into the central nervous system using intracisternal or intracerebroventricular delivery.

Total RNAs were isolated from the striatal tissues and miRNA-sequencing was performed. AAV-PHP.Eb carrying miR-145-5p sponge was delivered by the Intracerebroventricular injection at 2 days prior to ...

One narcoleptic subject had a G→T transversion introducing a highly charged arginine into the poly-leucine hydrophobic core of the Hcrt signal peptide. This allele was not present in 212 control ...

The Hypothalamic-Pituitary-Adrenal (HPA) axis has an important role in maintaining the physiological homeostasis in relation to external and internal stimuli. The HPA axis dysfunctions were ...

Decades of research advances have established a central role for endogenous opioid systems in regulating reward processing, mood, motivation, learning and memory, gastrointestinal function, and pain ...

This approach uses mesenchymal stem cells isolated from a patient’s own fat tissue to treat neurodegenerative diseases. The stem cells are supposed to assist in repair of damaged tissue and ...

Department of Translational Biomedical Sciences, Graduate School of Dong-A University, Busan 49201, Korea ...