Scientists at Trinity College Dublin have discovered a new process in our immune systems that leads to the production of an ...

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In the present study, we show that systemic administration of β-glucan reprograms alveolar macrophages (AMs) in the lung via neutrophils and IFNγ signalling, in a Dectin1-independent manner. We ...

The Krebs cycle byproduct itaconate has recently emerged as an important metabolite regulating macrophage immune functions, but its role in tumor cells remains unknown. Here, we show that increased ...

Both M1-like and M2-like TAMs have distinct cell surface markers and functional factors. M1-like TAMs are induced by interferon-γ (IFN-γ), lipopolysaccharides (LPS) and tumor necrosis factor-α (TNF-α) ...

Anti-Inflammatory Effects Basic Experiments in Mice Macrophage Activating Factor markedly suppressed TNF-α and IL-1β production in response to LPS in both in vivo and in vitro studies involving ...

Mechanical control is fundamental for cellular localization within a tissue, including for tumor-associated macrophages (TAMs). While the innate immune sensing pathways cGAS-STING and RLR-MAVS impact ...

Background: Environmental lipopolysaccharide (LPS) and microbial component-enriched organic dusts cause significant lung disease. These environmental exposures induce the recruitment and activation of ...

In many ways, they coincide and overlap with the response to inflammation, because this process is accompanied by local hypoxia. In particular, macrophage immune cells depend on proteins that are ...

Despite existing evidence for tuning of innate immunity to different classes of bacteria, the molecular mechanisms used by macrophages to tailor inflammatory responses to specific pathogens remain ...