Another element in the leptin signaling pathway is α-melanocyte-stimulating hormone (α-MSH), which is actually a fragment of the precursor protein POMC. Mutations in the POMC gene cause a rare ...

Reiko Hanada; Hitoshi Teranishi; James Todd Pearson; Mamoru Kurokawa; Hiroshi Hosoda; Nobuhiro Fukushima; Yoshihiko Fukue; Ryota Serino; Hiroaki Fujihara; Yoichi Ueta ...

But in some individuals with obesity, this signaling system seems to malfunction—a condition known as leptin resistance, where high levels of leptin fail to curb hunger.

Current research focus in the Fukuda lab: Signaling mechanisms controlling neural leptin sensitivity A gut-brain signal that promotes obesity. A novel neural signaling pathway that may have an ...

A key function of IRS proteins in peripheral tissues is to couple insulin receptor activation to signaling via the PI3K signal transduction pathway, and in neurons, PI3K is implicated as a key ...

These alterations lead to changes in neuronal communication, increased expression of inflammatory markers, and disruptions in ...