In this study, the authors developed a cell-based screening assay for the identification of small molecule inhibitors of nonsense-mediated decay (NMD). They used it to validate a novel small molecule ...

The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China Clinical Cancer Institute of Nanjing University, ...

Phage therapies, though currently restricted to compassionate use ... eventually uncovering novel virome-triggered or virome-mediated disease mechanisms. The full understanding of virome structure in ...

Table 1 below provides an overview of the key features of a prokaryotic cell: Table 1. The structure and function of key prokaryotic cell structures. Prokaryotes have ribosomes but they are smaller ...

These exemplify two contrasting mechanisms for control of DNA break repair in which the RecBCD complex is either inhibited or co-opted for the benefit of the invading phage. Gp5.9 completely inhibits ...

The Ph.D.-C7C phage display library was bio-panned following the manufacturer’s protocol (New England Biolabs, Ipswich, MA, USA) with moderate modification. The library displayed seven random peptides ...

Here we review the biology of Pf phage and what is known about its contributions to pathogenesis and clinical disease. First, we review the structure, genetics, and epidemiology of Pf phage. Next, we ...