Virax Biolabs Group Limited (NASDAQ: VRAX) ("Virax" or the "Company"), an innovative biotechnology company focused on the detection of immune responses and diagnosis of viral diseases, today announced ...

▎药明康德内容团队编辑  结直肠癌（CRC）是全球第三大常见癌症，其死亡率不断上升。美国FDA已批准使用免疫检查点抑制剂（ICI）治疗CRC，包括PD-1抑制剂，然而超过85%具有pMMR/MSS特征的患者几乎无法从中受益。癌细胞具有高度的代谢状态， ...

在免疫学领域，CD8+T 细胞在抵抗病毒感染、癌症以及自身免疫疾病中扮演着至关重要的角色。 因此，准确预测 T 细胞受体（TCR，T cell receptor）与主要组织相容性复合物（MHC，Major Histocompatibility ...

Prostate cancer and other cancers characterized by “cold” tumors could become more responsive to checkpoint blockade if UBA1 is inhibited.

老规矩，奇点糕开头先问大家一个问题：在激活CD8+T细胞抗肿瘤免疫应答时，有哪些细胞会起到重要作用呢？回答树突状细胞（DCs）是肯定没问题的，它们的抗原呈递功能确实广为人知，但各位要记住了，从今天开始DCs可就不是问题唯一的“正解”了。因为在今天的《 ...

已经广泛证明，通过特异性抗体-抗原复合物将抗原靶向DEC-205，可以有效地摄取和呈递MHC I和MHC II复合物上的抗原，从而分别激活抗原特异性CD8+和CD4+T细胞 ... in Experimental Colitis in Mice" Eur J Microbiol Immunol (Bp) 6(1):1-8. Flow Cytometry Mitsuoka N, Iwagaki H, ...

1 Department of Computational Biology and Medical Sciences ... Major histocompatibility complex class II (MHC-II) is essential for immune surveillance within the TME. While MHC-II genes are typically ...

For in vitro GPX4 deletion, enriched CD8 + T cells from Gpx4 fl/fl-ERT2Cre-P14 mice were treated with 5 μM 4-OHT for 36 h before subjected to adoptive transfer. Liproxstatin-1 (Lip-1; S7699, Selleck, ...

Here the authors characterise bone marrow cells from PRCA patients by single cell sequencing showing hyperactive CD8 + T cells, impaired erythropoiesis, increase of MHC-I proteins and antigen ...