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破解实体瘤免疫治疗困局:从LAG-3/PD-1联合疗法看肿瘤治疗新范式
2025年肿瘤免疫治疗市场预计突破千亿美元规模,但晚期实体瘤患者中仍有超60%对PD-1单药治疗无响应。中山大学团队在《血液学与肿瘤学杂志》发布的重磅临床研究,揭示了LAG-3/PD-1双靶点联合疗法在鼻咽癌等实体瘤中的突破性进展,这项涉及全国多中心的Ib/II期试验不仅带来11.3%的3级以上不良反应率、33.3%鼻咽癌客观缓解率的亮眼数据,更可能重塑实体瘤免疫治疗格局。
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