NRG5051 is a first-in-class inhibitor of the mitochondrial permeability transition pore (mPTP) and is designed to penetrate the brain when taken orally. It has been shown in vitro to protect ...

Two prominent examples are the use of neurotoxins 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-Hydroxydopamine (6-OHDA). MPTP is a reliable dopaminergic neurotoxin that has been used ...

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