Most mutations that decreased antibiotic susceptibility were related to specific metabolic pathways. A MIC-increase to ...

It is now widely recognised that host–microbiome interactions play a major role in the control of energy metabolism and ...

Objectives To investigate the effect of the L-arginine metabolism on arthritis and inflammation-mediated bone loss. Methods L-arginine was applied to three arthritis models (collagen-induced arthritis ...

Drug addiction is a condition in which there is uncontrolled use of a substance with a harmful outcome. Drugs overstimulate the brain’s reward circuit, producing pleasure or euphoria. With repeated ...

Survival during fasting requires release of adipose tissue lipid stores and is thought to be dependent on canonical lipases, including the rate limiting action of adipose triglyceride lipase.

Many genetic variants in drug metabolizing enzymes and transporters have been shown to be relevant for treating psychiatric disorders. Associations are strong enough to feature on drug labels and for ...

7 Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France 8 Institut Cochin, INSERM, CNRS, Université de Paris, Laboratoire d'excellence GR-Ex, Paris, ...

Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou 325000, China ...

The authors surveyed nearly 350 people about how many attempts it took to quit a substance before they were finally able to maintain their sobriety - revealing which drugs could be the most addicting.

That included an addiction to heroin, which Dion first snorted at 14 and finally kicked, along with all other drugs, in 1968: the year of his comeback hit, “Abraham, Martin and John,” a folk ...

It’s time to move on from treating heroin as Europe’s main drug problem, according to the head of the European Union’s drugs agency. That’s not to say heroin isn’t still a major problem.

Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou ...