imperial.ac.uk Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that have a number of important physiological roles including remodelling of the extracellular matrix, facilitating ...

Professor AJ Freemont, Department of Rheumatology, Institute of Musculoskeletal Science, Stopford Building, University of Manchester, Manchester M13 9PT. OBJECTIVES Matrix metalloproteinases (MMPs) ...

Twenty-three secreted factors were upregulated, mainly collagens and matrix metalloproteinases (MMPs). The deregulation of collagens and MMPs was confirmed by Quantitative reverse transcription - ...

soton.ac.uk Background Matrix metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extracellular matrix and drive tissue remodelling, key processes in the pathogenesis of COPD. The ...

An enlarging family of matrix-metalloproteinases has been identified that are calcium-dependent enzymes which specifically degrade collagens and noncollagenous substrates (see [37] for review).

The pro-matrix metalloproteinases (pro-MPPs) play key parts in mediating inflammation and joint destruction in RA.9 The effects of D2E7 on levels of pro MPP-1 and 3 were investigated in a group of ...

The new treatment targets inflammation directly within the joints so that therapeutic agents are released only when needed.

A new blood test detects pancreatic cancer early, an ultra-high-energy neutrino sets a record, and the Earth’s core undergoes ...

These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

They are not inert or end stage cells, but are highly activated, producing procoagulant tissue factor and a host of inflammatory cell mediators such as tumour necrosis factor α (TNF α), interleukins, ...

Objectives Tendinopathy is a frequent clinical problem and represents an extraordinary health economic and socioeconomic ...

Several Tri-Valley high school students have been recognized by the Society for Science for their scientific aptitude and ...