NanoCas is the first ultracompact CRISPR system capable of efficient extrahepatic editing when delivered systemically using a single AAV vector. This work is published on bioRxiv in a preprint ...

such as the anti-CRISPR systems to counterattack bacterial CRISPR-cas systems, in a continuing evolutionary arms race between virus and host. In turn, it is fundamental to the survival of the ...

CRISPR/Cas systems are widespread RNA-mediated prokaryotic adaptive immune systems providing protection against invading nucleic acids 1. However, throughout evolution, this host defense system ...

Furthermore, combining CRISPR/Cas9-based gene editing with an ex vivo organ perfusion system would enable pre-implantation transcriptome editing of grafts. How to determine effective intervention ...

Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), Institute of Interdisciplinary Studies, College of Chemistry and Chemical Engineering, Hunan Normal ...

Britain’s prime minister announced the move ahead of a meeting with European leaders as the region reeled from President ...

P3 editing is based on the dual-component guide RNA of the native CRISPR-Cas9 system 4, but with the crRNA:tracrRNA dimerization domain replaced with two protein-binding RNA aptamers such as MS2 and ...

P3 editing is based on the dual-component guide RNA of the native CRISPR-Cas9 system (Jinek et al., 2012), but with the crRNA:tracrRNA dimerization domain replaced with two protein-binding RNA ...

Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Intellia's technology platform specializes in Clustered Regularly Interspaced Short ...

Feb. 25, 2025 — On Wednesday 26 February, a thermal imaging camera blasted off to the Moon as part of NASA's Lunar Trailblazer mission. This aims to map sources of water on the Moon to shed ...