为解决结直肠癌（CRC）治疗难题，研究人员开展 MLKL 与 HHT 联合治疗 CRC 的研究。结果发现二者联用可抑制 CRC 细胞自噬、触发 parthanatos 并抑制肿瘤生长。该研究为 CRC 治疗提供新方向，值得科研读者一读。

Objectives Recently, necroptosis has attracted increasing attention in arthritis research; however, it remains unclear whether its regulation is involved in osteoarthritis (OA) pathogenesis. Since ...

The cell nuclei were stained with hematoxylin for 3 min at 25°C. For immunofluorescence, after being incubated with primary antibodies (anti-cleaved-Caspase-3, anti-phospho-MLKL (S345), anti-F4/80, ...

Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China (X.H., J.Z., C.X., R.C., P.J., X.J., P.H ...

Previous work identified a critical role for MLKL, the key effector regulating necroptosis, but not RIP3, in mediating high fat diet-induced liver injury in mice. RIP1 and RIP3 have active N-terminus ...

The mechanism by which PRV induces cell death is still unclear. Recently, necroptosis was identified as a programmed process dependent on the receptor interacting protein kinase 3 (RIPK3) and mixed ...