除了细胞分裂次数达到极限外，物理损伤、营养不良或紫外线引起的DNA损伤等因素也会导致细胞衰老。研究人员最初认为，发生细胞衰老是为了防止受损细胞无限制地复制并引发癌症。在某种程度上可能的确如此，但如果细胞不是单纯地死掉，像可控的凋亡程序 ...

THE Home Development Mutual Fund, also known as the Pag-IBIG Fund, is bullish about a potential surge in housing loan applications following the exodus of Philippine Offshore Gaming Operators (Pogos) ...

CEBU, Philippines — After nearly two decades of planning and deliberation, the P16.9 billion New Cebu International Container Port (NCICP) in Barangay Tayud, Consolacion, Cebu officially broke ...

Background While p53 mutations occur early in Barrett’s oesophagus (BE) progression to oesophageal adenocarcinoma (EAC), their role in gastric cardia stem cells remains unclear. Objective This study ...

1Department of Obstetrics and Gynecology, Peking University Third Hospital, China 2Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China. 3Biobank, Peking ...

Human papilloma virus (HPV)-related lesions have been shown to be associated with the expression of the immunohistochemical (IHC) marker p16. Non-HPV-related tumors have been characterized by p53 ...

THE NATIONAL Government’s (NG) outstanding debt rose to a fresh high of P16.09 trillion as of end-November, partly reflecting the impact of the peso depreciation on the value of foreign obligations, ...

p53 is a transcription factor that regulates the expression of genes involved in tumor suppression. p53 mutations mediate tumorigenesis and occur in approximately 50% of human cancers. p53 regulates ...

For several decades, p53 has been detected in cancer biopsies by virtue of its high protein expression level which is considered indicative of mutation. Surprisingly, however, mouse genetic studies ...