Researchers reveal how aging impairs antitumor activity of CD8⁺ T cells
A research team from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences has revealed that aging specifically impairs the generation of CD8+ tissue resident memory ...
Armed robbery in Revesby14d
Aging Reduces CD8+ T Cell Antitumor Activity
In a study published in Nature Aging on Nov. 26, a research team from the Shanghai Institute of Nutrition and Health (SINH) ...
The EMBO Journal9h
Acquired resistance to PD-L1 inhibition enhances a type I IFN-regulated secretory program in tumors
Acquired resistance to PD-L1 inhibition can rewire the interferon-regulated secretory machinery in tumor cells, altering the ...
News Medical on MSN12d
Phase 1 study finds serine- and glycine-free diet boosts immune response in colorectal cancer
Findings indicate a serine/glycine-free diet can reduce colorectal cancer growth and enhance immune response, offering ...
生物谷22d
《自然·通讯》：东南大学团队发现，PD-1还能变着花样促癌！
PD-1^28对CD8 + T细胞抗癌能力的负向调控在小鼠身上得到证实 研究者们表示，本次研究提示PD-1^28可能是人体内的潜在免疫检查点，乃至通过免疫抑制 ...
【转发】Nature Aging|肖意传研究组等研究发现衰老导致T细胞抗肿瘤免疫失能机制
伴随着衰老过程，人类患癌症风险上升。普遍认为，个体衰老进程导致DNA损伤和原癌基因激活，进而诱导细胞发生癌前病变。有研究提出，免疫衰老是衰老个体共有的生理现象。免疫衰老是伴随年龄增长出现的免疫系统的退行性改变，是导致个体“免疫力”下降进而诱发包括肿瘤 ...
科学家揭示衰老抑制T细胞抗肿瘤免疫机制
中国科学院上海营养与健康研究所、中国科学院上海药物研究所等单位的研究人员合作，揭示了衰老影响机体CD8+T细胞抗肿瘤免疫反应的作用和分子机理，探究了衰老个体和PD-1抗体治疗不响应患者的肿瘤免疫防御能力缺陷的机制，并指出衰老调控的关键靶点双功能细胞凋亡调控因子（BFAR）在治疗中具有重要意义。相关研究成果近日在线发表于《自然-衰老》。