This important chronobiological study in mice suggests that light modulated activity of Cdk5 activity on the PKA-CaMK-CREB signaling pathway provides missing molecular mechanistic details to ...

与此同时，科学家们发现运动表现和肠道微生物群关系紧密。一些肠道细菌可以帮助人们提升耐力、减轻炎症，运动也会反过来改变肠道微生物的组成。比如给长跑运动员补充均匀拟杆菌（Bacteroides uniformis），能促进肝脏产生葡萄糖，进而提升耐力；马拉松运动员肠道里的非典型韦荣氏球菌（Veillonella atypica）可以把运动产生的乳酸转化为丙酸，延长耐力运动时间。而且，CBD ...

Study shows that cannabidiol (CBD) enhances endurance exercise in mice by reshaping gut microbiota, boosting mitochondrial ...

In the hypothalamus, asprosin enhances the activity of AgRP neurons through activating G proteins-cAMP-PKA pathway, leading to increased appetite. In the liver, asprosin binds to OLFR734 to enhance ...

FIGURE 2. Molecular mechanisms of the signaling pathways involved in PDE4B. PDE4B is involved in the PI3K/AKT/mTOR signaling pathway and the other is through specific hydrolysis of cAMP followed by ...

生命科学Life science欢迎阅读2024年Cell ...

1Department of Obstetrics and Gynecology, Peking University Third Hospital, China 2Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China. 3Biobank, Peking ...

While the societal and human cost of opioid use disorder is now widely recognized, there are still few evidence-based interventions to treat those experiencing addiction, including strategies for the ...