In addition to pathogen-elicited inflammatory Th17 cells, commensal-elicited homeostatic Th17 cells can become conditionally pathogenic and contribute to the development of inflammatory depression.

Detecting danger is key to the survival and success of all species. Animal nervous and immune systems cooperate to optimize danger detection. Preceding studies have highlighted the benefits of ...

From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.) Faculty of Medicine, University of Freiburg, Germany (D.W.) K. Ley has received research funding for ...

The immune response plays an important role in disease; however, immune-mediated mechanisms of pathogenesis and regulation are not understood. In this study, we determined that a pathogenic Th17 ...

Other signaling pathways of AIM2. In BMDMs, AIM2 forms PANoptosome with Pyrin, ZBP1, ASC, etc., inducing cell pyroptosis, apoptosis, and necrosis; In Th17 cells, the interaction between AIM2 and RORγt ...

Important Note: Pathogen Safety Data Sheets (PSDSs) are technical documents used by individuals working with pathogens in the laboratory. To obtain any other information about infectious diseases, ...