eLife1 个月
SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C ...
During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...
NME1 个月
BBC Radio 1 Big Weekend 2025: Sam Fender, Wet Leg, Myles Smith and Blossoms lead line-up
CREDITS: Roberto Ricciuti/Redferns/Getty (L), Lorne Thomson/Redferns/Getty (C-L), Matthew Baker/Getty (C-R), Prince Williams/WireImage/Getty (R) BBC Radio 1 has announced the first line-up and ...
Frontiers2 年
Targeting the recurrent Rac1P29S neoepitope in melanoma with heterologous high-affinity T ...
Recurrent neoepitopes are cancer-specific antigens common among groups of patients and therefore ideal targets for adoptive T cell therapy. The neoepitope FSGEYIPTV carries the Rac1P29S amino acid ...
Frontiers3 年
Identification of PCBP1 as a Novel Modulator of Mammalian Circadian Clock
Transient expression vectors were generated by inserting cDNA into the multi-cloning site of pcDNA3.1(+)/hygro. Small interfering RNA (siRNA) of PCBP1 and PCBP2 were synthesized as follows: siPCBP1-1, ...
eLife9 年
Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense ...
We show that the polypyrimidine tract binding protein 1 (PTBP1) shields specific retroviral and cellular transcripts from NMD. When bound near a stop codon, PTBP1 blocks the NMD protein UPF1 from ...