Idiopathic pulmonary fibrosis (IPF) and diabetes mellitus do not appear to have a causal association, according to study findings published in Thorax.

The following is a summary of “Causal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample Mendelian randomization study,” published in the November 2024 ...

Many of our academics speak to the media as experts in their field of research. If you are a journalist, please contact the University’s Media and PR Team: ...

In 2019 an international team of researchers identified 109 genes that were associated in different combinations with eight different psychiatric disorders, including autism, ADHD, schizophrenia, ...

However, several limitations should be considered when interpreting our findings. First, the influence of potential pleiotropy still could not be completely ruled out, though weak evidence of ...

Antagonistic Pleiotropy This theory posits that some genes that are beneficial in early life for reproductive success may have harmful effects in later life. For example, genes that enhance immune ...

Many of our academics speak to the media as experts in their field of research. If you are a journalist, please contact the University’s Media and PR Team: I am a psychiatric genetic epidemiologist, ...

For individual SNPs, estimated causal effects were expressed as the odds ratios (ORs) from the Wald ratio method. After MR analysis, sensitivity analysis, including heterogeneity and pleiotropy, was ...

We suggest that paralogs can overcome the obstacle of structural pleiotropy by regulatory evolution at the transcriptional and post-translational levels. Mutations in paralogous proteins originating ...