Baylor College of Medicine3y
Adenovirus Vectors
The adenovirus vector is released with Pac I and then 293 cells are transfected to make the final recombinant adenovirus vector. In the VDL, all adenovirus vectors are produced in compliance with GLP ...
Baylor College of Medicine3y
In-Stock Adenoviral Vectors
Ad5-CMV-dsRed This recombinant human adenovirus type 5 expresses Discosoma sp. red fluorescent protein (dsRed) under the control of CMV promoter. Ad5-CMV-dsRed serves as a control for other ...
Nature6y
Three is the magic number in gene therapy production
Accordingly, the large majority of recombinant adeno-associated virus ... cultured cells would first be infected with adenovirus, after which they would be transfected with two DNA plasmids ...
Nature10y
Researchers and regulators reflect on first gene therapy death
The Recombinant DNA Advisory Committee (RAC ... his death by citing numerous changes needed to increase the safety of adenovirus vectors. They also proposed revising RAC guidelines for reporting ...