在动物实验中，研究人员建立了乳腺癌细胞异种移植裸鼠模型。结果显示，高剂量的龙葵碱对肿瘤的生长抑制作用比低剂量组和阳性对照药长春新碱更明显。龙葵碱可以降低肿瘤组织中 p - ERK 的阳性表达，减少 ERK2/MAPK 信号通路相关标记物的表达。同时，龙葵碱能激活铁死亡，使肿瘤组织中相关指标发生变化，加入 TPA 会逆转这些变化，而 Era 能部分挽救 TPA ...

ROS 2 support packages for Nova.

There are seven recognized families of bees in the world: Apidae, Megachilidae, Halictidae, Colletidae, Melittidae, Andrenidae, and Stenotritidae. Apidae is the largest family of bees, with over 5,700 ...

Ozone therapy is a controversial alternative medicine practice that involves using ozone gas to fight disease. Currently, there is not enough evidence to conclude it is effective or safe for ...

They also influence the mitogen-activated protein kinase (MAPK) signaling pathway ... preventing excessive ROS generation. Additionally, these bioactives influence the unfolded protein response ...

Maikel Rheinstadter receives funding from the National Science and Engineering Council Canada (NSERC), the Canadian Foundation for Innovation (CFI), the Province of Ontario and McMaster University ...

Diabetic nephropathy (DN) is the main cause of end-stage renal disease (ESRD), which is characterized by a series of abnormal changes such as glomerulosclerosis, podocyte loss, renal tubular atrophy ...

Defining life Defining life is surprisingly challenging. While we intuitively recognize living organisms as having life, a precise definition remains elusive. Dictionaries offer various ...

A 5-year-old boy is dead after a hyperbaric chamber he was inside exploded at a medical facility Friday in Troy, Michigan, police and fire officials said. The unidentified victim was inside the ...

'After a few weeks, I was able to start being able to think clearly, which I hadn’t been able to do in months.' TROY, Mich. (WXYZ) — As the Troy fire and police ...

Scientists recently reported an unexpected deep-sea development in the Pacific: certain metallic rocks seem to be making oxygen in the dark, without light or sunshine, at the bottom of the ocean. This ...

Materials Science Division, Argonne National Laboratory, Lemont, Illinois 60439, United States Institute of Chemistry, University of Campinas, Campinas, SP 13083-862, Brazil Institute of Chemistry, ...