Reactive oxygen species (ROS) from mitochondria are key drivers of genetic chaos in cancer by causing the ... The findings identify key proteins in this destructive process – p62 and CHMP7 – revealing ...

In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...

This study presents important findings on cold tolerance shared between hibernating and non-hibernating mammals, identifying a key molecule, GPX4, through multi-species genome-wide CRISPR screens. The ...

Cannabis exposure leads to genetic damage and accelerated aging, raising concerns about its transgenerational health effects ...

Focusing on the radiosensitizing potential of the currently approved drugs known to cross the blood ... #A1410), a transcriptional inhibitor to deplete mitochondrial RNA (mtRNA), and ROS inhibitor ...

Shaanxi Academy of Traditional Chinese Medicine (Shaanxi Provincial Hospital of Chinese Medicine), No.4 Xihuamen, Xi’an 710003, China ...