Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China ...

Department of Interventional Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Zhejiang Key Laboratory of Imaging and Interventional Medicine, ...

IL-18BP acts as a decoy receptor, hindering IL-18-mediated tumour-infiltrating lymphocyte activation. The company is developing bifunctional cytokine molecules, IL-18-FHAB-IL12 and IL-18-FHAB. These ...

Kesmalea’s SELFTAC® platform is designed to solve the ‘size problem’ of large, bifunctional protein degraders by transforming them into small molecules SELFTAC drug candidates will combine ...

Kesmalea’s SELFTAC® platform is designed to solve the ‘size problem’ of large, bifunctional protein degraders by transforming them into small molecules SELFTAC drug candidates will combine oral dosing ...

These molecules are designed to self-assemble to form the full bifunctional degrader at the intended location in the body. Their small size greatly facilitates oral bioavailability and the ability ...

Kesmalea’s SELFTAC® platform is designed to solve the ‘size problem’ of large, bifunctional protein degraders by transforming them into small molecules SELFTAC drug candidates will combine oral dosing ...

When the researchers put them through their paces, only three performed well — meaning that the antibodies bound to the protein of interest without binding to other molecules. But not one ...

Scientists have broken a 100-year-old chemistry rule to synthesize a class of molecules previously thought to be too unstable to form. The molecules in question violate Bredt's rule, which ...

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