The team mixes bundles of microtubules—biopolymers crucial for ... from cell alignment in tissues to the mitotic spindle organization during cell division. "Beyond confirming a theory, this ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Polyglutamylation is a reversible ...

Aurora-A is an essential cell-cycle kinase with critical roles in mitotic entry and spindle dynamics. These functions require binding partners such as CEP192 and TPX2, which modulate both kinase ...

To pull it off, these microscopic hollow tube structures, called “microtubules,” don’t rely on our everyday flavor of classical physics. Instead, experts believe, microtubules perform ...

However, the direct effects of SSNA1 on microtubules are not known. We employed in vitro reconstitution with purified proteins and TIRF microscopy to investigate the activity of human SSNA1 on dynamic ...

and cortical polarity domains exerting different effects on spindle astral microtubules. By systematically varying mitotic cell shape, we could modulate the effect of attractive and repulsive polarity ...