A patient with sickle cell disease died while participating in a clinical trial of a CRISPR-based treatment from Beam Therapeutics, threatening to overshadow early signals of effective gene editing.

ZUG, Switzerland and BOSTON, Nov. 05, 2024 (GLOBE NEWSWIRE) -- CRISPR Therapeutics (Nasdaq: CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article.

But as it turns out, CRISPR/Cas9 gene editing is a completely ... with Emmanuelle Charpentier’s investigation of the Streptococcus pyogenes bacterium. She was trying to understand how its ...

A concerning increase in global rates of severe invasive infections becoming resistant to key antibiotics has a team of infectious disease researchers at the Houston Methodist Research Institute ...

Jennifer Doudna, the co-developer of CRISPR, says there’s a “coming revolution” in climate-adapted crops and animals. Jennifer Doudna, one of the inventors of the breakthrough gene-editing ...

Closely related to group A streptococcus (also commonly known as Streptococcus pyogenes), which has been very well studied, little is known about SDSE. "Given its great emerging importance to ...

(11,12) The structural analysis of the CRISPR/Cas9 system has been greatly facilitated by the atomic resolution of crystal structures of Streptococcus pyogenes Cas9 in complex with RNA and DNA. The ...

CRISPR/Cas9 is a gene editing tool that has revolutionized biomedical research and led to the first FDA-approved CRISPR-based gene therapy. However, until now, the precise mechanism of exactly how ...

Biomolecular interactions, including contacts between biological macromolecules (protein/protein or protein/nucleic acids) and protein-ligand interactions are central to biochemistry. This grouping ...