Methods and results: LX-1 and LX-2 were generated by either SV40 T antigen immortalisation (LX-1) or spontaneous immortalisation in low serum conditions (LX-2). Both lines express α smooth muscle ...

Antigen processing and presentation is the mechanism by which whole antigens are degraded and loaded onto MHC molecules for display on the cell surface for recognition by T cells. Both macrophages ...

Then, the cells were immortalized by co-introduction of human telomerase reverse transcriptase (hTERT) and Simian virus 40 large T antigen (LT-SV40) via a lentivirus infection system. After clonal ...

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case ...

Duct ligations and adenovirus injections (see below) were performed 12 days after the last day of treatment. 266-6 cells, an acinar cell line derived from a mouse pancreatic tumour induced with an ...

Chimeric antigen receptor T-cells targeting the CD19 antigen have achieved impressive results in patients with relapsed/refractory (R/R) B-cell malignancies, leading to their approval in the European ...

T-Mobile is one of the fastest-growing carriers in the United States thanks to aggressive pricing, marketing, and a penchant for doing the unexpected. The Uncarrier has significantly shaken up the ...

Re “Why water systems aren’t designed for huge fires” (Feb. 10): The article by Tom Majich forgets two simple truths: 1) with adequate hydraulic pressure (read: full reservoirs), all fire ...

"We must be at the same level, parents and teachers. Schools can't be prisons when homes are safe havens for misbehaving," Mr Tuzareirwe said. He was speaking during a thanksgiving ceremony at ...