Figure 1: Bovine adrenocortical cells were established in culture and transfected with SV40 large T-antigen and the catalytic protein component of telomerase (hTERT). Slowing the rate of telomere ...

ATLANTA — The US Institute of Medicine (IOM) is looking into whether polio vaccines contaminated with the simian virus SV40 — thought to inactivate p53 and Rb — and given 40 years ago have caused a ...

The pRB polypeptide is also a major target of several DNA virus oncoproteins (adenovirus E1A, SV40 T antigen, and papillomavirus E7). These viral proteins bind and inactivate pRB. This inactivation of ...

It turned out that the increase in the expression of the p53 protein was caused by the stabilization of the protein through its interaction with SV40 large T antigen. This exciting discovery ...