The precise organization of pre- and postsynaptic terminals is crucial for normal synaptic function in the brain. In addition to its canonical role as a neurotrophin-3 receptor tyrosine kinase, ...

When Aβ aggregates stoke synaptic fires, tau tangles put them out. This phenomenon, demonstrated in animal models, now gains support in a human study, published September 18 in Nature Neuroscience.

To address this, researchers from University of Tsukuba focused on synaptic connections between neurons. They developed a novel molecular tool, SYNCit-K, which enhances synaptic strength ...

These findings strongly support the role of CaMKII as a molecular storage device. The article addresses the ‘decades-old’ unresolved question as to whether CaMKII is required for the maintenance of ...

Here, we provide evidence that inhibition of group III mGluRs by specific antagonists permits an NMDA receptor- and protein synthesis-dependent long-lasting synaptic potentiation in the apparently ...