Sosei Heptares has signed up a string of big pharma collaborators over the last few years, and one of them – AbbVie – has just expanded its partnership with a new to deal to apply the biotech ...

In addition, GUIDE-seq results demonstrated dramatically decreased number of off-target sites. For example, among the 134 off-target sites of one sgRNA targeting VEGFA with SpCas9, only 19, 24, and 18 ...

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.analchem.4c05325. Additional data on the impact of flow rate ...

A pipeline for the analysis of CRISPR edited data. It allows the evaluation of the quality of gene editing experiments using targeted next generation sequencing (NGS) data (`targeted`) as well as the ...

SHANGHAI and REDWOOD CITY, Calif. , May 29, 2024 /PRNewswire/ — HuidaGene Therapeutics (“HuidaGene”), a global clinical-stage biotechnology company focused on advancing CRISPR-based genomic medicines, ...

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REDWOOD CITY, Calif. and WALTHAM, Mass., Jan. 23, 2024 /PRNewswire/ — Synthego, a leading provider of genome engineering solutions, and SeQure Dx, a company focused on off-target analysis for ...

Media was changed to OptiMEM (ThermoFisher) and cells were transfected with 500 ng homologous recombination template and 1.3 μL of 3 μM sgRNA stock (Synthego) targeting the locus of interest ... the ...

To obtain high densities of sgRNA that would give signals significantly above the intracellular fluorescent background, especially when the chromatin is in open state during G and S phases ...