B, a transcription factor, is essential for maintaining X chromosome inactivation in T cells, connecting immune activation to ...

Instead, early IL-2 production by the T cells during their initial contact with LSECs was found to be responsible for overriding the tolerogenic response. Functional inactivation of IL-2 by ...

reuma.umcn.nl Objectives To investigate the role of X chromosomal inactivation (XCI) in systemic sclerosis (SSc) and its effects on forkhead box P3 (Foxp3) expression in T regulatory cells (Tregs).

In this manuscript, Ridout et al. present an intriguing extension of beta cell mass-focused models for diabetes. Their model incorporates reversible glucose-dependent inactivation of beta cell mass, ...

X chromosome inactivation (XCI) is the mechanism which randomly silences one X chromosome to equalise gene expression between 46, XX females and 46, XY males. Though XCI is expected to result in a ...