A major part of the drug development process is to weed out those compounds whose side effects overwhelm their therapeutic effects. This gets to the fundamental issue of efficacy vs effectiveness.

These drugs are useful, but they are also toxic, and the window for dosing to induce the desired therapeutic effect before causing toxicity is very narrow. The major toxicity related to ...

Panelists discuss how the Bayesian network meta-analysis showed which Janus kinase (JAK) inhibitors were most effective in ...

Researchers at the Icahn School of Medicine at Mount Sinai have developed a powerful computational tool, named iDOMO, to ...

Peptide therapy enhances targeted medicine, utilizing specific peptides for effective treatment of cancer, metabolic disorders, and neurodegenerative diseases.

A new study reveals that entacapone, a drug used to treat Parkinson’s disease, significantly disrupts the gut microbiome by ...

Ideally, for any drug, all of the unwanted effects would be in the former category and all of the therapeutic effects would be in the latter category. There are many examples of side effects of ...