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间充质干细胞:点亮视网膜退行性疾病治疗新希望的神奇 “钥匙”
比如,MSCs 可以通过抑制 HMGB1/TLR4 信号通路,促进小胶质细胞向 M2 型极化,有效减轻视网膜炎症;还能通过抑制 Toll 样受体 4(Toll - like Receptor 4,TLR4)信号,下调促炎因子和胶质细胞激活标记物,保护视网膜结构完整性,减少神经元凋亡。 抗氧化应激作用 ...
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