Successful research in targeted protein degradation depends not only on measurements at high sensitivity, speed and precision ...

Such interplay is seen with ADP-ribosylation and ubiquitylation. For example, DELTEX E3 ligases were reported to ubiquitylate a hydroxyl group on free NAD + and ADP-ribose in vitro, generating a ...

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Pharmaceutical scientists at the National University of Singapore (NUS) have developed a novel chemical reaction that enables ...

Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules such as nucleic acids and proteins that carry out the biological ...

Molecular glue degraders are small molecules that promote the interaction of a target protein with an E3 ubiquitin ligase ... A cryo-EM structure of UM171 associated with LHC and KBTBD4 revealed ...

While the exterior of vertebrate bodies appears bilaterally symmetrical, internal organ positioning and morphology frequently exhibit left-right (L-R) asymmetries. In several vertebrates, including ...