Successful research in targeted protein degradation depends not only on measurements at high sensitivity, speed and precision ...

E1s and E2s first work generically across the cell to activate and prepare ubiquitin for attachment. E3 ligases then ensure that the tag is added to the right protein; as such, hundreds of specific ...

Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding ...

One of the first things that students learn when they enter a biology class is the central dogma: DNA → RNA → ...

LC3/GABARAP is a family of ubiquitin-like proteins that mediate protein–protein interactions at every step of the autophagy pathway. Genetic knockdowns and knockouts of LC3/GABARAP proteins inhibit ...

When my co-founder and I started Invoice Home, we wanted to build a business that could grow over time. We noted many inefficiencies while discussing our past experiences working within ...

Defects in ubiquitin–UBD interactions are relevant for development of disease, such as inflammation and cancer. The new structure-based insights provide strategies for the design of new ...

Figure 1: Domain structure of ubiquitin-specific proteases. DUB activities fall into three major functional categories (Fig. 3). First, ubiquitin can be transcribed from several genes as a linear ...

We determine the crystal structure of the C-terminal part of IFT172, uncovering a conserved U-box-like domain often found in E3 ubiquitin ligases. This domain exhibits ubiquitin-binding properties and ...

Table 1 below provides an overview of the key features of a prokaryotic cell: Table 1. The structure and function of key prokaryotic cell structures. Prokaryotes have ribosomes but they are smaller ...

Ring finger protein 213 (RNF213) is a large E3 ubiquitin ligase with a molecular weight of 591 kDa that is associated ... As a result, studying the protein is difficult, and further research is ...