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Human leukocyte immunoglobulin (Ig)-like receptors (LILR) are a family of 11 innate immunomodulatory receptors, primarily expressed on lymphoid and myeloid cells. LILRs are either activating (LILRA) ...

A successful allotransplant would depend on tolerance, which depends on each individual NK cell expressing inhibitory receptors for two completely disparate sets of MHC molecules on donor and host ...

the considerable success achieved with hu5C8 reported here strongly supports careful study of a regimen based on this antibody to prevent rejection in human allotransplant recipients. The antibody ...

Background/Aims: Chimeric antigen receptor (CAR) T cells for refractory or relapsed (r/r) B-cell acute lymphoblastic leukemia (ALL) patients have shown promising clinical effectiveness. However, the ...