Treatment with tuspetinib in combination with Venclexta and Vidaza in newly diagnosed acute myeloid leukemia showed safety ...

Spheroid proliferation incubated for 5 days was measured through the WST-1 assay (Roche Applied Science), and then after 48 h, other groups of spheroids were measured to compare drug sensitivity to ...

Two examples of these types of drugs are 5-azacytidine and 5-aza-2′-deoxycytidine (Egger et al., 2004). These medications work by acting like the nucleotide cytosine and incorporating themselves ...

Mutations in chromatin modifying genes frequently occur in many kinds of cancer. Most mechanistic studies focus on their canonical functions, while therapeutic approaches target their enzymatic ...

HDACi 治疗对髓系恶性肿瘤中 CD47 表达的影响 研究人员还分析了公开的临床试验数据集，该数据集来自使用 entinostat 联合 5 - azacytidine 治疗血液系统恶性肿瘤的患者。结果发现，治疗后患者 CD34⁺细胞中 CD47 的表达显著升高。这说明，HDAC 抑制也可能增强恶性 ...

Here, the authors developed a cell-based screening assay for the identification of small molecule inhibitors of nonsense-mediated decay (NMD), and used it to validate KVS0001, a new small molecule ...

2 Department of Rheumatology and Clinical Immunology, Semmelweis University, Budapest, Hungary 4 Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary 5 Heart and ...

The Plinia (ex Myrciaria) genus is a member of the Myrtaceae family and contains several species and hybrids such as Plinia peruviana, P. jaboticaba and P. cauliflora, among others, popularly known as ...