In the atherosclerotic lesion microenvironment, VSMCs dedifferentiate and proliferate. This aberrant phenotypic switching of VSMCs is a crucial step in the development of AS (Figure 4). SMC ...

While our cells differentiate and stay that way, plant cells can dedifferentiate and then grow into a whole new plant. This is why plant propagators can take a small piece of a plant leaf ...

Small-cell lung cancer (SCLC) is a refractory cancer with rapid growth and high aggressiveness. Extensive-stage SCLC is initially sensitive to chemotherapy; however, drug resistance and recurrence ...

Objective Precancerous metaplasia transition to dysplasia poses a risk for subsequent intestinal-type gastric adenocarcinoma. However, the molecular basis underlying the transformation from ...

ABSTRACT: Vascular smooth muscle cells (VSMCs) in the arterial walls play important roles in regulating vascular contraction and dilation. VSMCs actively remodel the arterial walls and dedifferentiate ...

To overcome these limitations, a new strategy is required to efficiently produce fragmented fiber-type porogens without any complicated and labor-intensive protocols ...

2 Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel Objective Growing evidence ...