Introduction: CD38 is an ectoenzyme that is the main determinant of NAD + level. We have shown that the brain CD38 expression and enzymatic activity are increased in the setting of hypertension (HTN) ...

Nat Med. 2005;11(2):118-119. The ACE enzyme, a target of blood pressure medications, now gains a new function in mice. The enzyme cleaves proteins linked to the cell membrane by GPI linkages, an ...

Imbalance between effector and regulatory cells permits liver damage perpetuation and progression in AIH. Impaired expression and regulation of CD39, an ectoenzyme key to immunotolerance maintenance, ...