Here, the authors show that the unusual chromosome size-dependent DNA replication timing in Leishmania is influenced by RNA-DNA hybrids that are recognised by the endonuclease RNase H1.

Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the double strand break can result in insertion or deletion mutations, while repair pathways can be ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Endonuclease III (EndoIII), a key enzyme in the base excision repair (BER) pathway, ...

1 Noteworthy among the recent advancements are SHERLOCK (Specific High-sensitivity Enzymatic Reporter unlocking) 3,4 and DETECTR (DNA Endonuclease Targeted CRISPR Trans Reporter) 4. CRISPR ...

The evidence that introns can influence different levels of transfer of genetic information between DNA and the final product is increasing. Longer first introns were found to be a general property of ...