Figure 1 Human and murine DDX3X isoforms. Shown are the different isoforms of the human (upper part) and murine (lower part) DDX3X proteins. The variant 4 isoform of the human DDX3X lacks the 185 ...

In addition, helicases are required for the replication of infectious viruses. Structural studies of small molecule inhibition of helicase action provide insight into their function as molecular ...

1Department of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. 4Department of Urology, Shanghai ...

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Assembly Bio said that it plans to advance ABI-1179 directly into the Phase 1b portion of the study, which will include ...

为解决肝细胞癌（HCC）预后差、缺乏有效生物标志物的问题，研究人员开展了 RECQL4 在 HCC 中作用的研究，发现其可预测预后、影响药物敏感性，对 HCC 治疗意义重大。 肝细胞癌（Hepatocellular carcinoma，HCC），这个隐匿在人体肝脏内的 “健康杀手”，一直以来都是全球癌症领域的一大难题。它不仅是全球第六大常见癌症，更是癌症相关死亡的第三大主因。多数 HCC ...

Haisco Pharmaceutical Group Co. Ltd. has described Werner syndrome ATP-dependent helicase (WRN; RECQ3; RECQL2) inhibitors reported to be useful for the treatment of cancer.

State of New Jersey Common Pension Fund D boosted its holdings in IDEAYA Biosciences, Inc. (NASDAQ:IDYA – Free Report) by ...

Assembly Biosciences (ASMB) announced positive interim Phase 1a results in healthy participants from its ongoing Phase 1a/b study of ABI-1179, ...

BACKGROUND: Circular RNAs derived from both nuclear and mitochondrial genomes are identified in animal cells.