Statins lower plasma cholesterol by upregulating LDL receptor gene expression and are consequently relatively ineffective in homozygous familial hypercholesterolemia (HoFH). The standard treatment ...

Clin Lipidology. 2013;8(4):407-409. Homozygous familial hypercholesterolemia is a rare but significant cause of early-onset coronary heart disease. Early detection and diagnosis is crucial in at ...

Arrowhead Pharmaceuticals has sent an application to the New Zealand regulator seeking clearance to commence a Phase I/IIa trial of ARO-ALK7.

RHD zygosity testing can identify pregnancies that require RhD immunoglobulin, minimizing unnecessary treatments for HDFN.

Thus, only the double homozygous recessive genotype produces a phenotype with no color, and the resulting phenotypic ratio of color to noncolor is 15:1. Today, scientists know that Mendel's ...

The most updated set is significantly improved but isn’t telomere-to-telomere assembly. Burgess’ team successfully bred ...

Heterozygous familial hypercholesterolemia was associated with increased type 2 diabetes risk, especially among those with obesity and statin use.

Verve Therapeutics, a clinical-stage company developing a new class of genetic medicines for cardiovascular disease, today ...

And this was met by an arm we call modified titration. It met that primary objective and that ARIA-E frequency was 14% for the modified titration versus 24% for the standard dosing. And so this ...

Lexeo Therapeutics, Inc. (LXEO – Research Report), the Healthcare sector company, was revisited by a Wall Street analyst yesterday. Analyst ...