Clinical and lipidomic investigations of fibromyalgia were conducted for human validation. Results Using non-painful sound stimuli as psychological stressors, we demonstrated that mice developed ...

This comprehensive review summarizes and interprets the neurobiological correlates of nocebo hyperalgesia in healthy humans. Nocebo hyperalgesia refers to increased pain sensitivity resulting from ...

Central sensitization is a driving mechanism in many chronic pain patients, and manifests as hyperalgesia and allodynia beyond any apparent injury. Recent studies have demonstrated analgesic effects ...