Similarly, CIG still enhanced PP2A activity and inhibited tau hyperphosphorylation in LCMT-1 siRNA-transfecte cells. These results suggest that CIG may regulate methylation of PP2Ac not entirely ...

As a neurodegenerative disease, Alzheimer’s disease (AD) is characterized by synaptic loss, extracellular plaques of amyloid accumulation, hyperphosphorylation of tau, and neuroinflammation. Various ...

Tau hyperphosphorylation and conformational changes in the brain parenchyma start around seven months. Tangle-like pathology is mainly observed in the brain stem and spinal cord, and to a lesser ...

The hTau.P301S model recapitulates several molecular, cellular, and behavioral features of human tauopathy, including tau hyperphosphorylation, tau filament formation, neurodegeneration, and motor ...

Alterations in the expression and activity of specific translation factors, and the uncoupling of translational regulation from inhibition by tumour cell stresses, such as hypoxia and nutrient ...

Hyperphosphorylation of the tau protein can result in the self-assembly of intraneuronal tangles of tau filaments, which are involved in the pathogenesis of PSP and CBD. The chromosomal region ...

Department of Chemistry and R.N. Adams Institute for Bioanalytical Chemistry, University of Kansas, Lawrence, Kansas 66045, United States ...

Department of Health Industry Technology Management, Chung Shan Medical University, Taichung 40201, Taiwan Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, ...

Traumatic brain injury (TBI) leads to increased rates of dementia, including Alzheimer’s disease. The mechanisms by which trauma can trigger neurodegeneration are increasingly understood. For example, ...